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Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

PMID: 17049515

Principal component analysis (PCA) was conducted using MATLAB R2015a (The MathWorks, Natick, MA, USA) with the PLS Toolbox version 8.1 (Eigenvector Research, Inc., Manson, WA, USA)

Lysosomotropic agents, such as chloroquine (CQ), ammonium chloride (NH 4 Cl), and methylamine, accumulate in lysosomes, leading to lysosomal swelling and pH elevation 30,31,32

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The strongest activity resulted when an extract of the herb was given by injection, but ingesting the herb extract orally (at concentrations of 0.25 to 1.0 percent of the diet by weight) showed a 3.5- to 4.5-fold increase in GST activity, which is very significant